|
Clomid is the anti-estrogen of choice for improving recovery
of natural testosterone production after a cycle, improving testosterone
production of endurance athletes, and is also effective in reducing
risk of gynecomastia during a cycle employing aromatizable steroids.
|
Product
|
Price
|
|
|
Clomid 50mg x 30 tablets By Aventis Pharma
|
$264.00
|
|
|
Generic Clomid 50mg x 30 tablets
|
$66.00
|
|
How it works
While it has been claimed that Clomid "stimulates"
production of LH and therefore of testosterone, in fact Clomid's
activity is achieved not by stimulation of the hypothalamus and
pituitary, but by blocking their inhibition by estrogen.
Clomid is a mixed estrogen agonist/antagonist (activator/blocker)
which, when bound to the estrogen receptor, puts it in a somewhat
different conformation (shape) than does estradiol. The estrogen
receptor requires binding of an estrogen or drug at its binding
site and also the binding of any of several cofactors at different
sites. Without the binding of the cofactor, the estrogen receptor
is inactive. Different tissues use different cofactors. Some of
these cofactors are able to bind to the estrogen receptor/Clomid
complex, but others are blocked due to the change in shape. The
result is that in some tissues Clomid acts as an antagonist -
the cofactor used in that tissue cannot bind and so the receptor
remains inactive - and in others Clomid acts as an agonist (activator),
because the cofactors used in that tissue are able to bind.
Clomid is an effective antagonist in the hypothalamus and in
breast tissue. It is an effective agonist in bone tissue, and
for improving blood cholesterol.
Clomid also has the property of reducing the adverse effect of
exercise-induced damage of muscle tissue. This is very significant
for endurance athletes but is not very significant, if at all
significant, with reasonable weight training. Clomid does not
perceptibly affect gains of the weight trainer either favorably
or adversely in my experience.
Women and Clomid
The drug seems to have estrogenic effects on mood, which can be
beneficial (improving relationships with women by improving empathy)
or can yield depression or PMS-like symptoms, but for most users
there is no significant effect either way.
The claim that duration of intake should not exceed 10-14 days
is incorrect. Clinical studies with male patients have been for
periods of a year or longer. This error probably originates from
the fact that, for use in women, due to the menstrual cycle there
would obviously be no point in trying to stimulate ovulation all
four weeks of the month. Thus, use in women is limited to 10-14
days. That limitation is not because of toxicity.
Clomid is in fact useful throughout a cycle if aromatizable drugs
are being used. We do think however that to be conservative, one
should use it no more than 2/3 of the time throughout the year
or a little less.
Usage:
Average dose is 1 tablet a day.
click
to order now!!!
|
